Propolis is a bee wax rich in various phytocomponents and traditionally used to treat various ailments. Molecules. The molecular targets of propolis and its bioactive compounds in inhibition of cell proliferation and cell survival and induces the cell cycle arrest in cancer cells. B., Schmid T., Dehne N., et al. The goal of the most recent study was to synthesize poly-(lactide-co-glycolide) acid (PLGA) nanoparticles for the encapsulation of Sonoran propolis (SP) as a matrix to increase the solubility of their polyphenolic compounds and improve delivery, and assess its antiproliferative activity on cancer cells. The Algerian propolis extract-treated cells showed reduced cell proliferation and inhibited the cell adhesion by altering the fibrinogen in lung cancer [74]. sharing sensitive information, make sure youre on a federal Because most of the activity is given by free forms, and conjugation makes it harder to demonstrate activity, bioavailability is directly connected with sensitivity to conjugation when the components are integrated through the intestines [60]. Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis. The Role of Propolis as a Natural Product with Potential Gastric Cancer Treatment Properties: A Systematic Review. 2021;71:209249. Please enable it to take advantage of the complete set of features! Propolis is a rich source of biologically active compounds, which affect numerous signaling pathways regulating crucial cellular processes. Pharmacokinetic properties of compounds present in Okinawa propolis (OP) were analyzed by molinspiration online toolkit to consider them as potent drug candidates based on its Lipinski's 5th rule [61]. The databases searched were Scopus, Pubmed, and Web of Science. Bethesda, MD 20894, Web Policies The aim of this review is to highlight and summarize the molecular targets and anticancer potential of propolis and its active compounds on cell survival, proliferation, metastasis, and apoptosis in cancer cells. Clin Exp Reprod Med. Regulation of apoptosis via propolis and its compounds. 2016 Nov;40:550-560. doi: 10.1016/j.intimp.2016.10.008. Careers. Cancer metastasis is a process involving cell invasion, cell migration, cell adhesion, extracellular matrix (ECM), and degradation of basement membrane by proteinase enzymes. eCollection 2022. Jonker J. W., Buitelaar M., Wagenaar E., et al. As a result, artepillin C, which is difficult to conjugate and has a strong affinity for cell membranes, is a potential bioavailable factor for use in degenerative disease chemoprevention. Please enable it to take advantage of the complete set of features! Berretta A. 10.1007/s12016-012-8322-2 Abstract Propolis, a waxy substance produced by the honeybee, has been adopted as a form of folk medicine since ancient times. Propolis: Benefits, Uses, and More Propolis has been carefully studied for decades and has been utilized as a folk medicine for thousands of years. With the right research, novel, low-cost cancer therapies can be produced from propolis. Disclaimer. We summarized the inhibitory effect of propolis on cancer cell proliferation and metastasis-related signaling pathways, and also propolis induces apoptosis by targeting both extrinsic and mitochondrial-mediated apoptotic signaling pathways. -, Zabaiou N., Fouache A., Trousson A., Baron S., Zellagui A., Lahouel M., Lobaccaro J.A. Several naturally obtained drugs like paclitaxel, vinblastine, vincristine, and several others are being clinically used as anticancer medicines. To propagate gastric cancer cells as highly proliferative stem-cell spheroids in vitro, we initially used a similar method to that for colorectal cancer stem cells, which, unfortunately, resulted in a low success rate (25%, 18 of 71 cases). Sajjadi SS, Bagherniya M, Soleimani D, Siavash M, Askari G. Sci Rep. 2023 Mar 17;13(1):4452. doi: 10.1038/s41598-023-31254-y. Khan T., Gurav P. PhytoNanotechnology: enhancing delivery of plant based anti-cancer drugs. doi: 10.1002/jsfa.10024. -, Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. -. As the principal bioactive components, artepillin C, kaempferide, dihydrokaempferide, isosakuranetin, and kaempferol were shown to contribute to the CYP450 inhibitory activity of a standardized propolis extract (EEP-B55). The .gov means its official. However, a study with tumor cell lineages revealed that different concentrations of red propolis are associated with different profiles of cytotoxicity [117]. Recent Progress in Medicinal Plants. Furthermore, Niyomtham et al. government site. Federal government websites often end in .gov or .mil. All of this evidence suggests that CAPE induces apoptosis in human multiple myeloma cells via oxidative stress [59]. Propolis capsules (400 mg, 3 times daily) is consumed for 10 days before radiotherapy, 10 days during radiation treatment, and 10 days after irradiation. The activity of CYP450 enzymes is crucial for therapeutic effectiveness since it has a major impact on the drug's concentration in circulation and its metabolites. Potential therapeutic strategies to treat cancer promotion and progression by propolis and its polyphenolic/flavonoid compounds. 8600 Rockville Pike Ren X., Liu J., Hu L., Liu Q., Wang D., Ning X. Caffeic acid phenethyl ester inhibits the proliferation of HEp2 cells by regulating stat3/plk1 pathway and inducing S phase arrest. Is Acetaminophen Beneficial in Patients With Cancer Pain Who - PubMed 2019;5:e01978. HPLC-ESI-TOF-MS was used to identify two flavonoids in EAEP: galangin and apigenin. Propolis has been proposed as a coadjuvant nutritional supplement in cancer treatment due to its functional characteristics and biological activities, such as antitumoral activity, DNA protection, free radical scavenging, and immune stimulation; however, clinical trials to support these effects in cancer patients are required. Epub 2011 Feb 1. Note: ROS, Reactive oxygen species; NO, Nitric oxide; NF-B, Nuclear factor kappa-light-chain-enhancer of activated B cells; UV, ultraviolet radiation; SOD, Superoxide dismutase; CAT, Catalase; Nrf2, nuclear factor E2-related factor 2; VEGF, Vascular endothelial growth factor; MMPs, Matrix metalloproteinases; GSH, Reduced glutathione; HIF-1, Hypoxia-inducible factor-1; Trx, Thioredoxin; TrxR, thioredoxin reductase. Federal government websites often end in .gov or .mil. Although propolis is a good source of minerals, amino acids, vitamins A, E, and B complex, and the biochemical compounds like bioflavonoids, phenols, aromatic compounds, and many other molecules, which possess hepatoprotective activity, anti-inflammatory, antiproliferative, antifungal, antibacterial, and antimicrobial qualities, the exact constituent of propolis is still unknown; hence, further research is required to find out the new compounds [31, 4951]. Rahman MA, Ahmed KR, Haque F, Park MN, Kim B. Antioxidants (Basel). Accessibility Sci. government site. doi: 10.2174/138920008785821657. As a result, it raises concerns about possible side effects from mixing propolis with other drugs owing to changes in CYP450 enzyme activity. doi: 10.5633/amm.2020.0215. ACS Omega. Cao B., Li S. T., Li Z., Deng W. L. Yiqi zhuyu decoction combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer. Characteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi Arabia. government site. A., et al. Several recent studies also reported that the anticancer properties of propolis and its active principle compounds such as CAPE, artepillin C, and chrysin have shown anticancer potential by apoptosis induction and inhibition of cell growth in different cancer cells [4346]. Propolis exerts anticancer effects primarily by inhibiting cancer cell proliferation, inducing apoptosis through regulating various signaling pathways and arresting the tumor cell cycle, inducing autophagy, epigenetic modulations, and further inhibiting the invasion and metastasis of tumors. A caffeic acid phenethyl ester analog inhibits the proliferation of nasopharyngeal carcinoma cells via targeting epidermal growth factor receptor. This site needs JavaScript to work properly. This site needs JavaScript to work properly. Antioxidant, antimicrobial, antiparasitic, and cytotoxic properties of various Brazilian propolis extracts. Curr. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Brazilian red propolis, a water-insoluble resinous mixture of the saliva of bees (Apis mellifera) and vegetable exudate, mainly from Dalbergia ecastaphyllum (L) Taub, has strong antioxidant activity and has been investigated and proposed as an inhibitor of angiogenesis [34, 115]. Did you know that honey isn't the only thing that bees make? J Diet Suppl. Hattori H., Okuda K., Murase T., et al. Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats. 2017;207:214222. It is crucial to understand which propolis components are bioavailable in the human body. Unauthorized use of these marks is strictly prohibited. Relationship between ROS, inflammation, cancer, and propolis compounds. Bethesda, MD 20894, Web Policies ACS Omega. Bankova V. Recent trends and important developments in propolis research. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. The https:// ensures that you are connecting to the Iqbal M., Fan T.P., Watson D., Alenezi S., Saleh K., Sahlan M. Preliminary studies: The potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Barrientos L., Herrera C. L., Montenegro G., et al. The site is secure. and transmitted securely. sharing sensitive information, make sure youre on a federal Therapeutic effects of HESA-A in patients with end-stage metastatic cancers. The propolis contains 24 to 26% of fatty acids, 18 to 20% of flavonoids, 0.5 to 2% of microelements, 15 to 18% of sugars, 5 to 10% of aromatic acids, 26% of esters, 2 to 3.3% of alcohol and terpenes, and 2 to 4% of vitamins [30, 31]. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. The chrysin acts as a possible replacement for the 5-FU and oxaliplatin combination to attain treatment strategy through autophagy for colorectal cancer therapy in the future [18]. This research received no external funding. Patients and methods: In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). 1Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India, 2Central Research Laboratory, Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, MAHER University, Enathur, Chennai, Tamil Nadu 631552, India, 3Central Research Laboratory, Swamy Vivekanandha Medical College Hospital and Research Institute, Elayampalayam, Tiruchengode, Namakkal, Tamil Nadu 637205, India, 4Zebrafish Developmental Biology Laboratory, AUKBC Research Centre, Anna University, Chromepet, Chennai 600044, India, 5Research Center for Cellular Genomics and Cancer Research, Sree Balaji Medical College and Hospital, Chromepet, Chennai 44, India, 6Department of Medical Biochemistry, College of Health Sciences, Dambi Dollo University, Dembi Dollo, Ethiopia. FOIA Disclaimer. Artepillin C, another form of propolis, is reported to induce cytotoxicity through activating apoptosis and necrosis and inhibits mitosis in melanoma and carcinomas cells [1]. On the other hand, they also have potential antitumor properties by different postulated mechanisms such as suppressing cancer cells proliferation via its anti-inflammatory effects; decreasing the cancer stem cell populations; blocking specific oncogene signaling pathways; exerting antiangiogenic effects; and modulating the tumor microenvironment. Honey bee products: preclinical and clinical studies of their anti-inflammatory and immunomodulatory properties.

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